Table 38.
Antifungal activity of polyhydroquinoline derivatives 51.
| |||||
|---|---|---|---|---|---|
| Compound | R | R1 | R2 | C. albicans | A. fumigatus |
| MIC (μg/mL) | MIC (μg/mL) | ||||
| 51a | 4-F | CN | 4-Cl | >1000 | >1000 |
| 51b | 4-F | COOEt | 4-Cl | 1000 | >1000 |
| 51c | 4-F | CONH2 | 4-Cl | 1000 | 500 |
| 51d | 4-F | CN | 4-Me | 500 | 500 |
| 51e | 4-F | COOEt | 4-Me | 500 | >1000 |
| 51f | 4-CF3 | CN | 4-Me | 1000 | >1000 |
| 51g | 4-CF3 | COOEt | 4-Me | 1000 | 1000 |
| 51h | 2,4-diF | CN | 4-Me | 500 | >1000 |
| 51i | 2,4-diF | COOEt | 4-Me | 500 | 100 |
| 51j | 2,4-diF | CN | 4-Cl | 250 | 1000 |
| 51k | 2,4-diF | COOEt | 4-Cl | 250 | 1000 |
| 51l | 2,4-diF | CONH2 | 4-Cl | 1000 | 100 |
| 51m | 4-F | CN | 4-F | 1000 | 1000 |
| 51n | 4-F | COOEt | 4-F | 250 | 1000 |
| 51o | 4-CF3 | CN | 4-F | 500 | 500 |
| 51p | 4-CF3 | COOEt | 4-F | 500 | 250 |
| Griseofulvin a | -- | -- | -- | 500 | 100 |
a Standard drug for the study.