Table 41.
Antifungal evaluation of pyrazole derivatives 9 and 10.
| |||||
|---|---|---|---|---|---|
| Compound | R | R1 | MIC (μg/mL) | ||
| Candida krusei | Aspergillus fumigatus | Aspergillus niger | |||
| 9a | 2-OHC6H4 | Me | 5.00 | 6.25 | 7.50 |
| 9b | 4-MeC6H4 | Me | 7.50 | 10.0 | 12.5 |
| 9c | 4-MeOC6H4 | Me | 3.75 | 5.00 | 7.50 |
| 9d | C6H5 | Me | 5.00 | 6.25 | 7.50 |
| 9e | 2-Furanyl | Me | 10.0 | 3.75 | 7.50 |
| 9f | 2-OHC6H4 | EtO | 12.5 | 8.75 | 6.25 |
| 9g | 4-MeC6H4 | EtO | 8.75 | 10.0 | 7.50 |
| 9h | 4-MeOC6H4 | EtO | 8.75 | 7.50 | 6.25 |
| 9i | C6H5 | EtO | 12.5 | 10.0 | 8.75 |
| 9j | 9-Anthracenyl | EtO | 12.5 | 5.00 | 7.50 |
| 9k | 2-Furanyl | EtO | 8.75 | 7.50 | 10.0 |
| 10a | 2-OHC6H4 | Me | 8.75 | 7.50 | 6.25 |
| 10b | 4-MeC6H4 | Me | 8.75 | 12.5 | 6.25 |
| 10c | 4-MeOC6H4 | Me | 6.25 | 10.0 | 3.75 |
| 10d | C6H5 | Me | 7.50 | 5.00 | 8.75 |
| 10e | 2-Furanyl | Me | 3.75 | 8.75 | 12.5 |
| Griseofulvin a | -- | -- | 3.12 | 1.25 | 1.25 |
| Nystatin a | -- | -- | 1.25 | 1.00 | 1.00 |
a Positive control for the study.