Table 47.

α-Amylase activity of 3-alkyl-1-(4-(aryl/heteroaryl)thiazol-2-yl)indeno[1,2-c]pyrazol-4(1H)-ones 37.

Compound	R	R1	IC50 (μM)
37a	Me	Biphenyl	5.29
37b	Et	Biphenyl	10.05
37c	iPr	Biphenyl	20.51
37d	iBu	Biphenyl	10.78
37e	Me	2-Naphthyl	6.88
37f	Et	2-Naphthyl	4.17
37g	iPr	2-Naphthyl	18.31
37h	iBu	2-Naphthyl	3.21
37i	Me	2-Benzofuranyl	0.94
37j	Et	2-Benzofuranyl	0.79
37k	iPr	2-Benzofuranyl	0.46
37l	iBu	2-Benzofuranyl	0.89
Acarbose a	--	--	0.11

^a Reference compound.