FIGURE 1.
Effects of peripheral and central serotonergic systems on blood glucose levels. 5-HT, 5-HT2 receptor, 5-HT receptor agonists, 5-HT4 receptor agonists, and 5-HT2c receptor agonists regulate blood glucose levels via the peripheral serotonergic system. 5-HT in the brain, pinealocytes, nucleus accumbens, and hypothalamus and 5-HT2C receptors in the hypothalamus and nucleus of the solitary tract are involved in modulating blood glucose levels via the central serotonergic system.