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. 2022 Jul 22;23(15):8062. doi: 10.3390/ijms23158062

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Inflammatory markers are upregulated by compressive forces in hPDL after 24 h. To analyze the regulation of inflammatory cytokines under compressive forces, the expression of different markers was analyzed on mRNA level (A) and protein levels (B) after mechanical stimulation. The pro-inflammatory cytokines interleukin-6 (IL-6), interleukin-8 (IL-8) and cyclooxygenase-2 (Cox2) are significantly upregulated. The vascular endothelial growth factor A (VEGFA), a mediator of inflammation and angiogenesis, is also significantly upregulated. The data represent two independent experiments in triplicates; normalization by ddC_t method to RPL22 and control 100% statistical data were tested for normal distribution by Shapiro–Wilk test and a t-test was performed. Statistically significant differences are marked by an asterisk (* p < 0.05, **** p < 0.0001).