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Stability of ibrutinib (A,B), dihydrodiol ibrutinib (C,D) and the active moiety (sum of ibrutinib and dihydrodiol ibrutinib concentrations) (E,F) in whole blood (A,C,E) and in plasma (B,D,F) at 25 °C over 6 h in 3 independent samples. The dashed line (- - -) displays the limit for judging analyte stability as acceptable (0.85).
