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. 2022 Jul 14;12:924354. doi: 10.3389/fonc.2022.924354

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Copyright © 2022 Pokorna, Hrabal, Tichy, Vojtesek and Coates

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decitabine reduces ΔNp63 and mRNA levels in squamous cells. (A) Representative Western blots and densitometric quantitation of ΔNp63 in HaCaT, FaDu and SCC-25 cells treated with the indicated concentrations of decitabine for four days. β-actin is shown as loading control. Densitometry data represent fold change ± SEM compared to untreated cells (0, DMSO only; n = 3 for each dose in each cell line) and normalized to β-actin. (B) ΔNP63 mRNA levels normalized to ACTB mRNA (n = 3 to 5 biological replicates, each with technical triplicates). Data are shown as fold change ± SEM compared to untreated cells (0, DMSO only). *p < 0.05; **p < 0.01; ***p < 0.001 compared to control.