Table 1.
The relationship between MPO expression and the clinicopathological features of CRC in TCGA.
| Characteristic | Low expression of MPO | High expression of MPO | p |
|---|---|---|---|
| n | 239 | 239 | |
| T stage, n (%) | 0.208 | ||
| T1 | 6 (1.3%) | 5 (1%) | |
| T2 | 48 (10.1%) | 35 (7.3%) | |
| T3 | 160 (33.5%) | 163 (34.2%) | |
| T4 | 24 (5%) | 36 (7.5%) | |
| N stage, n (%) | 0.739 | ||
| N0 | 146 (30.5%) | 138 (28.9%) | |
| N1 | 51 (10.7%) | 57 (11.9%) | |
| N2 | 42 (8.8%) | 44 (9.2%) | |
| M stage, n (%) | 0.004 | ||
| M0 | 182 (43.9%) | 167 (40.2%) | |
| M1 | 21 (5.1%) | 45 (10.8%) | |
| Pathological stage, n (%) | 0.003 | ||
| Stage I | 49 (10.5%) | 32 (6.9%) | |
| Stage II | 92 (19.7%) | 95 (20.3%) | |
| Stage III | 74 (15.8%) | 59 (12.6%) | |
| Stage IV | 21 (4.5%) | 45 (9.6%) | |
| Primary therapy outcome, n (%) | 0.402 | ||
| PD | 10 (4%) | 15 (6%) | |
| SD | 2 (0.8%) | 2 (0.8%) | |
| PR | 5 (2%) | 8 (3.2%) | |
| CR | 113 (45.2%) | 95 (38%) | |
| Sex, n (%) | 0.234 | ||
| Female | 120 (25.1%) | 106 (22.2%) | |
| Male | 119 (24.9%) | 133 (27.8%) | |
| Age, n (%) | 0.926 | ||
| <=65 | 96 (20.1%) | 98 (20.5%) | |
| >65 | 143 (29.9%) | 141 (29.5%) | |
| BMI, n (%) | 0.724 | ||
| <25 | 42 (16.4%) | 45 (17.6%) | |
| >=25 | 87 (34%) | 82 (32%) | |
| Residual tumor, n (%) | 0.215 | ||
| R0 | 172 (46%) | 174 (46.5%) | |
| R1 | 3 (0.8%) | 1 (0.3%) | |
| R2 | 8 (2.1%) | 16 (4.3%) | |
| CEA level, n (%) | 0.010 | ||
| <=5 | 107 (35.3%) | 89 (29.4%) | |
| >5 | 41 (13.5%) | 66 (21.8%) | |
| Perineural invasion, n (%) | 0.372 | ||
| NO | 68 (37.6%) | 67 (37%) | |
| YES | 19 (10.5%) | 27 (14.9%) | |
| Lymphatic invasion, n (%) | 0.054 | ||
| NO | 139 (32%) | 127 (29.3%) | |
| YES | 71 (16.4%) | 97 (22.4%) | |
| History of colon polyps, n (%) | 0.989 | ||
| NO | 133 (32.6%) | 129 (31.6%) | |
| YES | 75 (18.4%) | 71 (17.4%) | |
| Colon polyps present, n (%) | 0.963 | ||
| NO | 82 (32.9%) | 80 (32.1%) | |
| YES | 43 (17.3%) | 44 (17.7%) | |
| OS event, n (%) | 0.045 | ||
| Alive | 197 (41.2%) | 178 (37.2%) | |
| Dead | 42 (8.8%) | 61 (12.8%) | |
| DSS event, n (%) | 0.011 | ||
| Alive | 209 (45.2%) | 189 (40.9%) | |
| Dead | 22 (4.8%) | 42 (9.1%) | |
| PFI event, n (%) | 0.005 | ||
| Alive | 189 (39.5%) | 161 (33.7%) | |
| Dead | 50 (10.5%) | 78 (16.3%) |