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. 2022 Jul 24;23(15):8152. doi: 10.3390/ijms23158152

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Immunohistochemical labeling of cones and ipRGCs in different models. From left to right, the different animal models are presented (C57BL/6J; Opn4^−/−; Rd10; Opn4^−/− × Rd10). From top to bottom, the different agents and antibodies used are presented. DAPI: intercalating marker of cell nuclei; Calbindin (Calbn): protein located in the horizontal cells; Cone Arrestin (CAR): cone labeler; Melanopsin (Mel): melanopsin labeler, located in the ipRGCs; ipRGCs are marked by white arrowhead. The bottom row shows: “Merged” of different labelings. Opn4^−/− × Rd10 animal model showed total absence of cells with photosensitive capacities. The scale bar indicates 50 µm.