Figure 3.

A schematic diagram summarizing the functions of Hericium erinaceus in AD. Abbreviations: ROS, Reactive oxygen species; BAX, Bcl-2- associated X protein; TBARS, Thiobarbituric acid reactive substances; MDA, Malondialdehyde; Nrf2, Nuclear factor-erythroid factor 2-related factor 2; SOD, Superoxide dismutase; CAT, Catalase; GSH, Glutathione; Bcl-2, B-cell lymphoma 2; SDS, Sodium dodecyl sulfate; CTF-β, Beta-carboxyl-terminal fragment; Aβ, Amyloid-beta; IDE, Insulin-degrading enzyme; iNOS, Nitric oxide synthase; ASC, Apoptosis-associated speck-like protein containing a caspase recruitment domain; NLRP3, NLR family pyrin domain containing 3; NF-kB, Nuclear factor-kappa B; ACh, Acetylcholine; ChAT, Choline acetyltransferase; TrkA, Tropomyosin receptor kinase A; RAS-GTP, Ras protein guanine triphosphatase; Raf, Rapidly accelerated fibrosarcoma; MEK, Mitogen-activated protein kinase; Erk, Extracellular signal-regulated kinase; CREB, cAMP-response element binding protein.