Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 22;14(15):3575. doi: 10.3390/cancers14153575

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Different therapeutic strategies for overcoming drug resistance with ICIs. There are two main strategies for improving ICI therapy effectiveness and reducing the number of patients with ICI resistance. The first strategy is to improve immune cell infiltration in TME by some cytokines or chemokines, and enhance T cell recognition for tumor cells. The second strategy is to increase the concentration of tumor antigens in THE TME by biological, physical, or chemical methods to facilitate antigen presentation by APC. In addition, the combination of different ICI types may also produce synergistic antitumor effects.