Figure 5.

Functional clustering annotation of N-glycoproteins with down-regulation of the high-mannose-type induced by 2DG. (A) The enriched biological processes associated with the down-regulation of the high-mannose-type, including the integrin−mediated signaling pathway, lysosomal transport, protein targeting to lysosome, protein hydroxylation, and protein N-glycosylation via asparagine, etc. (B) The corresponding enriched molecular functions, including virus receptor activity, exogenous protein binding, integrin binding, transferase activity, transferring hexosyl group, retromer complex binding, and collagen binding, etc. (C) Exemplification of the functional clusters of glycoproteins with down-regulated high-mannose, hybrid, and complex types. (D) Exemplification of networks of biological processes involved in glycoproteins with down-regulated N-glycosylation with high-mannose, hybrid, and complex types.