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The influence of 2-Deoxy-D-glucose (2DG) on tumor cells. 2DG inhibits the growth and survival of cancer cells by interfering with the ATP produced by the metabolism of D-glucose. In addition, 2DG can inhibit protein glycosylation in vivo by competing with D-mannose, leading to endoplasmic reticulum (ER) stress and misfolded protein responses in cancer cells.
