Table 3.

Univariable (A) and multivariable (B,C) analyses for adverse pathological findings.

A: Univariable Analysis of Mixed Effects Model
Variables of Model	Odds Ratio	p Value
Sub-group (Compared to Very low sub-group)
Low	1.46 (1.15, 1.86)	<0.001
Age, years	1.04 (1.02, 1.06)	<0.001
PSA level, ng/mL	1.07 (1.01, 1.14)	0.029
PSA density, ng/mL/cm3	16.62 (2.96, 98.67)	<0.001
Number of biopsy cores with prostate cancer	1.16 (1.05, 1.29)	<0.001
Last biopsy time since AS, months	1.01 (1.00, 1.01)	0.015
Number of biopsies	1.22 (1.07, 1.40)	<0.001
Reasons leaving AS (Compare to Protocol reasons)
No evidence of progression	0.44 (0.22, 0.84)	0.016
Others	0.54 (0.37, 0.76)	0 < 0.001
B: Multivariable analysis of mixed effects model
Variables of Model	Odds Ratio	p Value
Sub-group (Compared to Very low sub-group)
Low	1.37 (1.07, 1.76)	0.014
Age, years	1.05 (1.06, 1.07)	<0.001
PSA level, ng/mL	1.04 (0.98, 1.11)	0.180
Last biopsy time since AS, months	1.01 (1.00, 1.01)	0.152
Number of biopsies	1.14 (0.95, 1.37)	0.166
Reasons leaving AS (Compare to Protocol reasons)
No evidence of progression	0.48 (0.24, 0.92)	0.034
Others	0.61 (0.42, 0.88)	0.009
C: Multivariable analysis of mixed effects model including PSA density and number of biopsy cores containing cancer (sub-group excluded)
Variables of Model	Odds Ratio	p Value
Age, years	1.05 (1.03, 1.07)	<0.001
PSA level, ng/mL	0.99 (0.92, 1.07)	0.862
Last biopsy time since AS, months	1.00 (1.00, 1.01)	0.361
Number of biopsies	1.20 (0.99, 1.47)	0.069
PSA density, ng/mL/cm3	23.21 (3.01, 196.12)	0.003
Number of biopsy cores with prostate cancer	1.16 (1.05, 1.29)	0.004
Reasons leaving AS (Compare to Protocol reasons)
No evidence of progression	0.53 (0.26, 1.00)	0.061
Others	0.67 (0.46, 0.96)	0.031

CIs: 95% confidence intervals.