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. 2022 Jul 25;11(15):2294. doi: 10.3390/cells11152294

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Manipulating miR-31 alters cell proliferation post-radiation treatment. (A) Assaying cumulative proliferation with radiation treatment revealed no significant decrease in cell count at any time points measured in BxPC-3-miR-VC irradiated cells (4 Gy) compared to mock-irradiated cells (0 Gy). MiR-31-expressing irradiated cells displayed a significant decrease in cell count at day 3 (* p = 0.0353) compared to their mock-irradiated counterpart. (B) A significant reduction in cell count was displayed at day 3 (** p = 0.00122) and day 6 (* p = 0.0120) in Panc-1 Zip-miR-VC irradiated cells compared to mock-irradiated cells, while Zip-miR-31 irradiated cells displayed a reduction in cell count at day 3 only (* p = 0.0354) compared to mock-irradiated cells. Data are expressed as the mean ± SEM (n = 3). Two-way ANOVA with Tukey’s post-hoc test was adopted for statistical analysis.