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. 2022 Jul 25;11(15):2294. doi: 10.3390/cells11152294

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Manipulating miR-31 alters apoptosis in PDAC cells. Caspase 3/7 activity was measured as a marker of apoptosis at 20 min, 4 h, and 24 h post-radiation treatment (RT). (A) There were no significant differences in apoptosis in 20 min post-RT (p > 0.999) between BxPC-3 miR-VC and BxPC-3 miR-31 cells. However, overexpressing miR-31 in BxPC-3 cells displayed a significant increase in apoptosis 4 h (**** p < 0.0001) and 24 h (**** p < 0.0001) post-RT. (B) There are no significant differences in apoptosis 20 min post-RT between Panc-1 Zip-miR-VC and Panc-1 Zip-miR-31 cells (p = 0.9368). Although suppressing miR-31 in Panc-1 cells displayed a significant decrease in apoptosis 4 h (* p = 0.0199) and 24 h (** p = 0.00630) post-RT. Data are represented as the mean ± SEM (n = 3). Two-way ANOVA with Tukey’s post-hoc test was adopted for statistical analysis.

Manipulating miR-31 alters apoptosis in PDAC cells. Caspase 3/7 activity was measured as a marker of apoptosis at 20 min, 4 h, and 24 h post-radiation treatment (RT). (A) There were no significant differences in apoptosis in 20 min post-RT (p > 0.999) between BxPC-3 miR-VC and BxPC-3 miR-31 cells. However, overexpressing miR-31 in BxPC-3 cells displayed a significant increase in apoptosis 4 h (**** p < 0.0001) and 24 h (**** p < 0.0001) post-RT. (B) There are no significant differences in apoptosis 20 min post-RT between Panc-1 Zip-miR-VC and Panc-1 Zip-miR-31 cells (p = 0.9368). Although suppressing miR-31 in Panc-1 cells displayed a significant decrease in apoptosis 4 h (* p = 0.0199) and 24 h (** p = 0.00630) post-RT. Data are represented as the mean ± SEM (n = 3). Two-way ANOVA with Tukey’s post-hoc test was adopted for statistical analysis.