Table 1.

Accelerated approvals by decade cohort: converted, withdrawn, pending completion [5]

1992–2001 summary data		2002—2011 summary data		2012—2021 summary data
Total accelerated approvals granted	52	Total accelerated approvals granted	59	Total accelerated approvals granted	167
Converted	44	Converted	44	Converted	51
Confirmatory trials pending	2	Confirmatory trials pending	3	Confirmatory trials pending	102
Of 44 converted, average time to confirm clinical benefit was 4.5 years, with a median of 3.9 years		Of 44 converted, average time to confirm clinical benefit was 5 years, with a median of 4.1 years		Of 51 converted, average time to confirm clinical benefit was 2.5 years, with a median of 2.3 years
Of 6 withdrawn, the average time to withdrawal was 8.9 years, with a median of 10.4 years		Of 12 withdrawn, the average time to withdrawal was 9.9 years, with a median of 9.7 years		Of 14 withdrawn, the average time to withdrawal was 3.7 years, with a median of 3.5 years