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. 2022 Jul 22;14(15):3567. doi: 10.3390/cancers14153567

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Differences in protein profiles between leukemic blasts and healthy HSCs and HPCs. (a) PCA of leukemic blast and healthy immature cell subset protein expression pattern. Color-coding and the sample ID of the leukemic samples are indicated. The leukemic blasts from pAML23 and pAML29 were situated separated from the other leukemic and healthy subsets. The leukemic blasts from pAML17, pAML20, and pAML21 were positioned parallel to the healthy progenitor subsets. (b) Volcano plot displaying differentially abundant proteins between PC1 and HSCs. A total of 62 proteins were differentially expressed (p-value < 0.05). Upregulated: red spheres. Downregulated: green spheres. The labeled proteins are listed in Table S5. (c) Volcano plot displaying differentially abundant proteins between BC1 and HSCs. A total of 132 proteins of differential abundance were identified (p-value < 0.05) Upregulated: red spheres. Downregulated: green spheres. The labeled proteins are listed in Table S6.

Differences in protein profiles between leukemic blasts and healthy HSCs and HPCs. (a) PCA of leukemic blast and healthy immature cell subset protein expression pattern. Color-coding and the sample ID of the leukemic samples are indicated. The leukemic blasts from pAML23 and pAML29 were situated separated from the other leukemic and healthy subsets. The leukemic blasts from pAML17, pAML20, and pAML21 were positioned parallel to the healthy progenitor subsets. (b) Volcano plot displaying differentially abundant proteins between PC1 and HSCs. A total of 62 proteins were differentially expressed (p-value < 0.05). Upregulated: red spheres. Downregulated: green spheres. The labeled proteins are listed in Table S5. (c) Volcano plot displaying differentially abundant proteins between BC1 and HSCs. A total of 132 proteins of differential abundance were identified (p-value < 0.05) Upregulated: red spheres. Downregulated: green spheres. The labeled proteins are listed in Table S6.