Table 1.

Koch and Löffler 1884 postulates in their original formulation [14].

The microorganism must be found in abundance in all organisms suffering from the disease but should not be found in healthy organisms;

2.The microorganism must be isolated from a diseased organism and grown in pure culture;

3.The cultured microorganism should cause disease when introduced into a healthy organism;

4.The microorganism must be reisolated from the inoculated, diseased experimental host and identified as being identical to the original specific causative agent.