Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Outcomes of various dermatokinetic parameters (mean ± SD) of lidocaine-loaded gel formulations.
| Dermatokinetic Parameters | Nanogel | Conventional Gel | ||
|---|---|---|---|---|
| Epidermis | Dermis | Epidermis | Dermis | |
| Cmax (mg/cm2) | 2.64 ± 0.02 | 2.53 ± 0.06 | 1.48 ± 0.02 | 1.46 ± 0.04 |
| Tmax (h) | 0.83 ± 0.29 | 1.33 ± 0.58 | 1.33 ± 0.58 | 1.67 ± 0.58 |
| AUC0–12 h (mg/cm2h) | 26.15 ± 0.92 | 26.39 ± 0.91 | 14.13 ± 0.49 | 14.40 ± 0.18 |
| Ke (h−1) | 0.016 ± 0.004 | 0.010 ± 0.001 | 0.02 ± 0.01 | 0.021 ± 0.004 |
