Figure 2.

Kinetics of the voltage-dependent inactivation of Ca_V1.2^WT and Ca_V1.2^L566P. (A) Averaged Ca_V1.2^WT (black) and Ca_V1.2^L566P (red) current traces at +20 mV recorded from a holding potential of −80 mV, with a voltage step of 1 s duration to +20 mV (n = 17 and n = 21, respectively). (B) Time constants of inactivation for Ca_V1.2^WT (black) (n = 16–17) or Ca_V1.2^L566P (red) (n = 19–21) at different potentials for the first 200 ms of inactivation derived by a mono-exponential fit. **, p < 0.01; *, p < 0.05.