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Heroin self-administration reduced single-pulse stimulated dopamine release, but not dopamine reuptake in the NAc core. (A) Representative traces of electrically-evoked dopamine in saline exposed (black) and heroin exposed (red) rats. (B) Stimulated dopamine release was significantly lower in heroin-exposed rats. (C) The maximal rate of dopamine uptake (Vmax) was not significantly different between saline and heroin-exposed rats. ** p < 0.01.
