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Presynaptic KOR activity on NAc dopamine terminals is increased by heroin self-administration. Selective kappa-opioid receptor agonist U50,488H (A) decreased percent baseline dopamine release in heroin exposed rats with (B) no significant difference in IC50 between saline exposed and heroin exposed rats, but (C) significant decreases in the U50,488H maximal effect in exposed rats. * p < 0.05; ns: not significant.
