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. 2022 Jul 25;23(15):8177. doi: 10.3390/ijms23158177

Figure 2.

Figure 2

Characterization of S of TRES6 escape variants. (A,B,D,E,G,H,J,K,M,N,P,Q) Percent inhibition of lentiviral vector particles pseudotyped with SARS-CoV-2 S carrying the indicated RBD and/or NTD mutations. IC50s of the indicated RBD (red) and NTD (blue) cluster antibodies are displayed in ng/mL in the brackets. (C,F,I,L,O,R) Binding of the RBD (red) and NTD (blue) cluster antibodies and an S2-binding antibody (grey) to S with the indicated mutations. The binding capacity of cluster 1 and cluster 2 antibodies to HEK-293T cells expressing SARS-CoV-2 S proteins carrying a T478I (C), T478I+N74K (F), and T478K (I); or T478K+I68R (L), S477N (O), and S477N+G261R (R). Neutralization and binding of the control D614G variant is given in Figure 5A–C.