Figure 3.

Summary of the antioxidants therapies proposed as good candidates to treat tauopathies. OS is a lineal process that start in the mitochondria by the production of ROS and, if is not prevented, ends with cellular damage and/or cell death. Antioxidants prevent OS by counteracting the damaging action of ROS. Antioxidant enzymes act in the first line of defense suppressing the generation of free radicals. Free radical-scavengers act in the second line of defense interacting with free radicals and neutralizing them to prevent cell damage. The third line of defense consists of restoring the impairment affected by free radicals and they work repairing the damage and reconstituting membranes. Tauopathies antioxidant therapies research has been focused on targeting the first two lines of OS defense by activating antioxidant enzymes and treating with free-radical scavengers. Because mitochondria is the first resource of ROS in the cells, mitochondria-targeting therapies have also been developed to reduce OS.