Table 1.

Effects of different metabolic engineering strategies on products.

Strains-Production	Relevant Characteristics	Culture Method	Titer (g/L)	Yield (mol/mol)	Productivity (g/L/h)	Source or Reference
E. coli W3110.shik1-SA	∆aroL, ↑aroGFBR, ↑aroFFBR,	Batch culture	ns	0.059	ns	[36]
B. megaterium MTCC428-SA	∆aroK	Batch culture	6	ns	ns	[38]
E. coli DHPYAAS-T7-SA	∆ptsHIcrr, ∆aroL, ∆ydiB, ↑aroE, ↑aroB, ↑glk, ↑tktA, ↑aroFfbr, ∆aroK	Shake flask	1.85	0.426	ns	[37]
C. Glutamicum-SA	∆qsuD, ∆qsuB, ∆aroK, ∆ptsH, and ∆hdpA, ↑tkt, ↑tal, ↑aroG, ↑aroBDE, ↑IolT1, ↑glk1, ↑glk2, ↑ppsk), ↑gapA	Fed-Batch	141	0.510	2.938	[51]
B. subtilis DE1-SA	∆aroA, ↑aroE130, ↑aroD	Shake flask	1.1	ns	ns	[35]
SK4/rpsM-SA	∆aroL, ∆aroK, ↑aroB, ↑aroG*, ↑ppsA, ↑tktA, ColE1 ori, kmr, rpsM, aroK	Shake flask	1.74	ns	ns	[39]
SK5/pSK6-SA	∆aroL, ∆aroK, ∆ydiB, ∆ppc,∆ldhA, ColE1 ori, aroB, tktA, aroG*, DHQ/SDH, rpsM, aroK, Sper	Shake flask	5.33	ns	ns	[39]
E. coli SP1.1/pKD12.112-SA	serA::aroB, aroL478::Tn10 aroK17::CmR, ↑aroFFBR, ↑PtacaroE	Fed-Batch	38	0.12	ns	[22]
E. coli SP1.1/pKD12.138-SA	serA::aroB, aroL478::Tn10, aroK17::CmR, ↑tktA	Fed-Batch	52	0.18	0.87	[13]
E. coli JB4/pJB5.291-SA	∆aroD, ∆aroE, ↑aroFFBR, ↑tktA, ↑aroD·E	Fed-Batch	34	0.15	0.52	[13]
E. coli PB12.SA22 ydiB-SA	∆ydiB, ∆aroL, ∆aroK, ↑pJLB aroGfbr, ↑tktA, ↑aroB, ↑aroE	Batch culture	8.2	0.24	ns	[42]
E. coli SP1.1/pKD12.138-SA	serA::aroB, aroL478::Tn10 aroK17::CmR, ↑tktA	Fed-Batch	35	0.19	0.73	[13]
E. coli SP1.1 PTS/pSC6.090B-SA	∆aroL, ∆aroK, ↑aroFFbr, ↑aroE, ↑glf, ↑glk, ↑tktA	Fed-Batch	87	0.36	5.2	[46]
E. coli SA 110-SA	↑aroGfbr, ↑tktA, ↑aroB, ↑aroE, ∆aroL, ∆aroK, ↓pps, ↓csrB	Shake flask	1.34	0.21	ns	[48]
E. coli SA 116-SA	↑aroGfbr, ↑tktA, ↑aroB, ↑aroE, ↑pntAB, ↑nadK, ∆aroL, ∆aroK, ↓pps, ↓csrB	Shake flask	3.12	0.33	ns	[48]
E. coli PB12.SA22-SA	↑aroGFBR, ↑tktA, ↑aroB, ↑aroE, ∆aroL, ∆aroK	Shake flask	7	0.29	ns	[43]
C. glutamicum RES167ΔaroK-SA	∆aroK, ↑RiboJ, GFP, (aroGMU, aroBMU, aroDMU, aroEMU) with various RBS	Fed-Batch	11.40	ns	ns	[60]
C. glutamicum TD -SA	↑tkt, ∆pyk	Shake flask	7.76	ns	ns	[54]
B. subtilis BSSA/Ωpyk::pSApyk-SA	↑aroD, ↑aroA, ∆pyk	Shake flask	3.46	ns	ns	[56]
E coli B0013 SA5/pTH-aroGfbr-ppsA-tktA-SA	∆aroL, ∆aroK, ∆ydiB	Shake flask	14.6	0.29	ns	[61]
E. coli HJS203	HJS200, Ampr, Cmr, p15A-PrpsL-tetR-LAA-Ptet-aroGfbr-PP9-tktA-PP9-aroBopt-aroE, pPMB1-PrpsA P1-aroK-DAS+4	Batch culture	14.33	0.23	ns	[62]
E. coli S8	E. coli MG1655, ΔptsHIcrr::Zmglf, ΔaroL::tktA, ΔaroK, PJ23119-GB, ΔaroK::rpE, ΔyidB, carrying pJ01-TetR(166)-TEVp(118), NX3	Fed-batch	76		1.05	[63]
E. coli AB2848aroD/pKD136/pTW8090A-QA	∆aroD, ↑qad (from Klebsiella pneumoniae), ↑tktA, ↑aroF, ↑aroB	Shake flask	10.7	ns	0.45	[10]
E. coli strain B-101-QA	∆aroD, ↑NtHQT, ↑4CL, ↑ydiB	Shake flask	0.45	ns	0.19	[72]
E. coli AB2834/pKD136/pKD8.243A-GA	↑aroE, ↑aroB, ↑aroZ(from K. pneumoniae), ↑aroY (from K. pneumoniae), ↑catA (from Acinetobacter calcoaceticus)	Shake flask	3.75	0.33	ns	[92]
E. coli KL7-GA	∆aroE, ↑aroGfbr, ↑aroZ, ↑pobA*, ↑aroB	Fed-Batch	20	0.12	0.42	[84]
strain Y385F/T294A-GA	↑ pobA*	Shake flask	1.15	ns	ns	[85]
E. coli JM12-pyrogallol	pCS-entCBA-APTA and pZE-nahGopt	Shake flask	1.04	ns	ns	[82]
RHY5-pyrogallol	aroL, ppsA, tktA, aroGfbr from E. coli, ubiC from E. coli, two operons, PLlacO1-cipA-Y385F/T294A pobA and PLlacO1-pdc and PLlacO1-PDC	Shake flask	0.08	ns	ns	[86]
W3110 trpD9923/pJLBaroGfbrtktA/pTrc-ant3-Catechol	ΔptsH, ptsI, ↑antABC, ↑aroGfbr, ↑tktA, ↑aroF, ↑aroB,	Fed-Batch	4.47	0.16	ns	[21]
E. coli WN1/pWL1.290A-Catechol	ΔaroE, ↑tktA, ↑aroB, ↑aroZ, ↑aroFfbr, ↑aroY,	Shake flask	8.50	7.00	ns	[94]
E. coli N74dpheA pUbic-PobA pECL	ΔpheA, ↑ubiC,↑pobA, ↑ECL	Batch culture	0.63	0.06	ns	[96]

ns, not specified. Up arrow, increased gene expression. Down arrow, decreased gene expression.