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Anal disease incidence in K14E6/E7 transgenic mice. Chi-square analysis and Fisher’s exact tests were performed, comparing no treatment to DHA only and DMBA only to DHA + DMBA. There were no statistically significant differences in final anal histology between treatment groups.
| Group | Non-Dysplastic | Low-Grade Dysplasia | High-Grade Dysplasia | Squamous Cell Carcinoma | Total |
|---|---|---|---|---|---|
| No treatment | 2 | 5 | 5 | 0 | 12 |
| DHA only | 0 | 4 | 5 | 0 | 9 |
| DMBA only | 0 | 0 | 3 | 9 | 12 |
| DHA + DMBA | 0 | 0 | 1 | 11 | 12 |
