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. 2022 Jul 26;14(8):1627. doi: 10.3390/v14081627

Figure 4.

Figure 4

SARS-CoV-2 infection induce lung ECM remodeling in K18-hACE-2 mice. Representative images and the corresponding quantification of lung sections labeled for collagen IV (A,E), laminin (B,F), WFA (C,G) and Masson’s trichrome (D) (MTC) at 2 and 5 days post SARS-CoV-2 infection compared to mock. For each group n = 6–8 mice and for each mouse, five fields were imaged and analyzed. Scale bar: (A–C) 50 µm, (D) 200 µm, inset 20 µm. (H) Representative soluble collagen accumulation in BALF samples of mice 2 and 5 days post SARS-CoV-2 infection compared to mock. (I) Quantification of soluble collagen concentrations in the BALF samples; (n = 6 mice for mock and n = 5 for 2 dpi and n = 8 for 5 dpi). The error bars represent the SEM. Statistical significance was calculated using Kruskal–Wallis nonparametric test * p < 0.05, ** p < 0.005, **** p < 0.0001.