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. 2022 Jul 26;12(8):687. doi: 10.3390/metabo12080687

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Multidimensional analysis of the association between gut microbiota and plasma metabolites. (A) Two-way orthogonal partial least-squares (O2PLS) analysis between gut microbes and plasma metabolites. X-axis represents the first principal component of metabolites, and Y-axis represents the first principal component of microbes. (B) Co-inertia analysis (CIA) of the relationship between microbiota and metabolites. (C,D) show the top 10 metabolites and microbes screened based on CIA, respectively.