Table 1.
Baseline and clinical characteristics of septic shock patients with and without neutropenia.
| Characteristics | All Patients (n = 43,466) |
Non-Neutropenic SS (n = 37,075) |
Neutropenic SS (n = 6391) |
p-Value |
|---|---|---|---|---|
| Age, years | 67.0 ± 12.7 | 67.8 ± 12.6 | 62.6 ± 12.9 | <0.001 |
| Sex, male | 28,067 (64.6) | 24,166 (65.2) | 3901 (61.0) | <0.001 |
| Comorbidities | ||||
| Hypertension | 23,136 (53.2) | 20,091 (54.2) | 3045 (47.7) | <0.001 |
| Diabetes mellitus | 16,977 (39.1) | 14,758 (39.8) | 2219 (34.7) | <0.001 |
| Congestive heart failure | 5745 (13.2) | 5008 (13.5) | 737 (11.5) | <0.001 |
| Chronic lung disease | 5008 (11.5) | 4301 (11.6) | 707 (11.1) | 0.213 |
| Renal failure | 2783 (6.4) | 2397 (6.5) | 386 (6.0) | 0.199 |
| Liver cirrhosis | 4974 (11.4) | 4705 (12.7) | 269 (4.2) | <0.001 |
| CCI (mean) | 6.30 ± 3.89 | 6.29 ± 3.91 | 6.36 ± 3.80 | 0.186 |
| CCI (subgroup) | ||||
| 0–2 | 7816 (18.0) | 6709 (18.1) | 1107 (17.3) | |
| 3–4 | 9652 (22.2) | 8160 (22.0) | 1492 (23.4) | |
| 5–7 | 8256 (19.0) | 7231 (19.5) | 1025 (16.0) | |
| 8+ | 17,742 (40.8) | 14,975 (40.4) | 2767 (43.3) | |
| Cancer type | <0.001 | |||
| Brain | 772 (1.8) | 736 (2.0) | 36 (0.6) | |
| Lung | 6657 (15.3) | 5646 (15.2) | 1011 (15.8) | |
| Liver | 6238 (14.4) | 6074 (16.4) | 164 (2.6) | |
| Colon | 4494 (10.3) | 4122 (11.1) | 372 (5.8) | |
| Stomach | 3684 (8.5) | 3284 (8.9) | 400 (6.3) | |
| Gall bladder | 1981 (4.6) | 1911 (5.2) | 70 (1.1) | |
| Pancreas | 1943 (4.5) | 1799 (4.9) | 144 (2.3) | |
| Leukemia | 1917 (4.4) | 1,053 (2.8) | 864 (13.5) | |
| Non-Hodgkin’s lymphoma | 1475 (3.4) | 724 (2.0) | 751 (11.8) | |
| Female reproductive system | 1249 (2.9) | 862 (2.3) | 387 (6.0) | |
| Breast | 1112 (2.6) | 752 (2.0) | 360 (5.6) | |
| Kidney/bladder | 1095 (2.5) | 1010 (2.7) | 85 (1.3) | |
| Multiple myeloma | 923 (2.1) | 635 (1.7) | 288 (4.5) | |
| Male reproductive system | 754 (1.7) | 641 (1.7) | 113 (1.8) | |
| Oropharynx | 439 (1.0) | 364 (1.0) | 75 (1.2) | |
| Esophagus | 391 (0.9) | 324 (0.9) | 67 (1.0) | |
| Thyroid | 169 (0.4) | 160 (0.4) | 9 (0.1) | |
| Larynx | 149 (0.3) | 131 (0.4) | 18 (0.3) | |
| Hodgkin lymphoma | 50 (0.1) | 28 (0.1) | 22 (0.3) | |
| Other, unspecified | 2995 (6.9) | 2564 (6.9) | 431 (6.7) | |
| Multiple | 4979 (11.5) | 4255 (11.5) | 724 (11.3) | |
| Treatment | ||||
| Radiotherapy within 30 days | 1607 (3.7) | 1272 (3.4) | 335 (5.2) | <0.001 |
| Chemotherapy within 30 days | 8310 (19.1) | 4693 (12.7) | 3617 (56.6) | <0.001 |
| Radiotherapy within 90 days | 3723 (8.6) | 3019 (8.1) | 704 (11.0) | <0.001 |
| Chemotherapy within 90 days | 13,831 (31.8) | 9425 (25.4) | 4406 (68.9) | <0.001 |
| Outcome | ||||
| 30-day mortality | 22,639 (52.1) | 19,797 (53.4) | 2842 (44.5) | <0.001 |
| 1-year mortality | 35,325 (81.3) | 30,369 (81.9) | 4956 (77.5) | <0.001 |
Values are expressed as the mean ± standard deviation or number (%). CCI, Charlson comorbidity index; SS, septic shock.