Table 1.
Demographic characteristics, comorbid conditions, hospitalization, intensive care unit (ICU) admission, and death from COVID-19 of subjects tested positive for SARS-CoV-2, stratifying by waves.
| First Wave (1 March–15 April 2020) N/Day a (%) |
Second Wave (15 October–15 December 2020) N/Day a (%) |
Third Wave (1 March–15 April 2021) N/Day a (%) |
p-Value b | |
|---|---|---|---|---|
| Age group | ||||
| ≤65 | 209.0 (51.6%) | 1797.3 (75.9%) | 1397.0 (78.5%) | <0.001 |
| 66–75 | 55.3 13.7%) | 216.4 (9.2%) | 196.4 (11.1%) | |
| 76–85 | 76.6 (18.9%) | 204.1 (8.6%) | 133.2 (7.5%) | |
| 86+ | 63.8 (15.8%) | 148.5 (6.3%) | 52.2 (2.9%) | |
| Gender | ||||
| F | 221.6 (54.7%) | 1275.8 (53.9%) | 900.3 (50.6%) | <0.001 |
| M | 183.2 (45.3%) | 1090.6 (46.1%) | 878.5 (49.4%) | |
| Charlson Comorbidity Index | ||||
| 0 | 238.7 (59.0%) | 1725.8 (72.9%) | 1343.5 (75.5%) | <0.001 |
| 1 | 89.5 (22.1%) | 436.1 (18.4%) | 317.3 (17.8%) | |
| 2–3 | 57.8 (14.3%) | 165.3 (7.0%) | 98.8 (5.6%) | |
| 4+ | 18.7 (4.6%) | 39.2 (1.7%) | 19.2 (1.1%) | |
| Chronic Obstructive Pulmonary Disease (COPD) | ||||
| No | 328.4 (81.1%) | 2019.2 (85.3%) | 1529.7 (86.0%) | <0.001 |
| Yes | 76.4 (18.9%) | 347.1 (14.7%) | 249.1 (14.0%) | |
| Cardiovascular disease | ||||
| No | 327.9 (81.0%) | 2151.7 (90.9%) | 1655.8 (93.1%) | <0.001 |
| Yes | 76.9 (19.0%) | 214.7 (9.1%) | 123.0 (6.9%) | |
| Heart failure | ||||
| No | 393.9 (97.3%) | 2344.1 (99.1%) | 1768.9 (99.5%) | <0.001 |
| Yes | 10.9 (2.7%) | 22.3 (0.9%) | 9.8 (0.5%) | |
| Coronary artery disease | ||||
| No | 385.5 (95.2%) | 2314.8 (97.8%) | 1747.1 (98.2%) | <0.001 |
| Yes | 19.3 (4.8%) | 51.6 (2.2%) | 31.6 (1.8%) | |
| Cardiomyopathy | ||||
| No | 385.9 (95.3%) | 2328.7 (98.4%) | 1761.8 (99.0%) | <0.001 |
| Yes | 18.9 (4.7%) | 37.7 (1.6%) | 17.0 (1.0%) | |
| Diabetes | ||||
| No | 340.4 (84.1%) | 2161.8 (91.3%) | 1647.6 (92.6%) | <0.001 |
| Yes | 64.4 (15.9%) | 294.6 (8.7%) | 131.1 (7.4%) | |
| Kidney disease | ||||
| No | 388.5 (96.0%) | 2330.7 (98.5%) | 1761.0 (99.0%) | <0.001 |
| Yes | 16.3 (4.0%) | 35.7 (1.5%) | 17.8 (1.0%) | |
| Cerebrovascular disease | ||||
| No | 379.8 (93.8%) | 2311.3 (97.7%) | 1755.5 (98.7%) | <0.001 |
| Yes | 25.0 (6.2%) | 55.1 (2.3%) | 23.3 (1.3%) | |
| Dementia | ||||
| No | 378.3 (96.2%) | 2340.1 (98.9%) | 1773.1 (99.7%) | <0.001 |
| Yes | 15.5 (3.8%) | 26.3 (1.1%) | 5.7 (0.3%) | |
| Neoplasia | ||||
| No | 384.2 (94.9%) | 2303.1 (97.3%) | 1735.5 (97.6%) | <0.001 |
| Yes | 20.6 (5.1%) | 63.3 (2.7%) | 43.3 (2.4%) | |
| Haematologic disease | ||||
| No | 402.3 (99.4%) | 2359.7 (99.7%) | 1774.8 (99.8%) | <0.001 |
| Yes | 2.5 (0.6%) | 6.7 (0.3%) | 3.9 (0.2%) | |
| Immunodeficiency | ||||
| No | 404.6 (99.9%) | 2365.7 (99.9%) | 1778.3 (99.9%) | 0.55 |
| Yes | 0.2 (0.1%) | 0.7 (0.1%) | 0.5 (0.1%) | |
| Hospitalization | ||||
| No | 240.1 (59.3%) | 2147.8 (90.8%) | 1596.8 (89.8%) | <0.001 |
| Yes | 164.7 (40.7%) | 218.6 (9.2%) | 182.0 (10.2%) | |
| Intensive care unit (ICU) admission | ||||
| No | 359.9 (88.9%) | 2312.7 (97.7%) | 1734.7 (97.5%) | <0.001 |
| Yes | 44.9 (11.1%) | 53.7 (2.3%) | 44.1 (2.5%) | |
| Death | ||||
| No | 332.3 (82.1%) | 2275.1 (96.1%) | 1732.1 (97.4%) | <0.001 |
| Yes | 72.5 (17.9%) | 91.3 (3.9%) | 46.6 (2.6%) |
a N/day average number of cases per day; b Comparisons among the three waves tested by Chi-square or Fisher test.