Table 3.
Effect of POE on the level of different pro-inflammatory cytokines in CCl4-treated mice.
| Groups | Pro-inflammatory cytokines (pg/mg protein) | ||
|---|---|---|---|
|
| |||
| TNF-α | IL-1β | IL-6 | |
| Control | 50.43 ± 1.97 | 170.67 ± 014.52 | 8.57 ± 0.53 |
| CCl4 (0.175% CCl4/olive oil) | 97.24 ± 2.31### | 1698 ± 48.66### | 31.35 ± 1.38### |
| Silymarin: 0.2 g/kg + CCl4 | 61.19 ± 2.18*** | 1002.17 ± 13.78*** | 16.88 ± 0.77*** |
| POE: 0.1 g/kg + CCl4 | 94.49 ± 1.36 | 1289.72 ± 69.91 | 28.66 ± 1.18 |
| POE: 0.5 g/kg + CCl4 | 83.04 ± 3.27 | 1128.10 ± 71.32** | 22.86 ± 2.01** |
| POE: 1.0 g/kg + CCl4 | 73.77 ± 11.27** | 874.05 ± 42.77*** | 18.36 ± 0.58*** |
#
Indicates significant difference from the control group (###p < 0.001).
*
Indicates significant difference from the CCl4 group (**p < 0.01, *** p < 0.001).
Values are mean ± SEM (n = 10).