Table 2.

AD-associated exosomes contain Aβ and tau.

Protein	Location	Species	The Uptake of Adjacent Cells	References
Aβ	SH-SY5Y cells and rat primary neurons	APP, AICD, C-terminal fragments (CTF)		[145]
	N2a cells	Aβ		[141]
	CHO-APP695 cells	CTF, APP, Aβ		[146]
	APP transgenic mice, brain from AD patients	CTF, APP, Aβ		[147]
	brain samples of temporal neocortex from AD subjects, SH-SY5Y cell	Aβ oligomers	Peripheral neurons	[137]
Tau	M1C cells and CSF samples from patients with AD	Phosphotau Species Associated with Neurodegeneration/dimerized or trimerized tau species		[142]
	N2a cells, rat primary neurons and CSF of patients with AD	Hypophosphorylated tau	Peripheral neurons	[148]
	transgenic mice with rapid tau propagation		Peripheral microglia	[149]
	lamprey CNS	hyperphosphorylated tau		[150]
	PS19 mice, CSF of patients with AD	p-Tau	Peripheral microglia	[151]
Aβ and tau	plasma or serum from AD patients	P-S396-tau, P-T181-tau, and Aβ1-42		[133,143]