ADAMTS	disintegrin and metalloproteinase with thrombospondin motifs
ANOVA	one-way analysis of variance
CaCo-2	the human immortalized colorectal adenocarcinoma cell line
CD44	differentiation cluster 44
COX-2	cyclooxygenase 2
DMEM/F12	Dulbecco’s modified Eagle’s medium/Nutrient F-12 Ham
EFSA	European Food Safety Authority
ELISA	Enzyme-Linked Immunosorbent Assay
EMA	European Medicines Agency
ERK	extracellular signal-regulated kinases
ERK/MAPK	mitogen-activated protein kinases/extracellular signal-regulated kinase
FBS	fetal bovine serum
FBS	fetal bovine serum
FDA	US Food and Drug Administration
GAGs	glycosaminoglycan heteropolysaccharides family
HA	hyaluronic acid
HMWHA	high-molecular weight HA
HPLC	High-Performance Liquid Chromatography
HRMS	high-resolution mass spectrometry
IBD	inflammatory bowel disease
IL-1β	interleukin (IL)-1β
LMWHA	low molecular weight HA
LPS	lipopolysaccharide
MTT	3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide
MMPs	matrix metalloproteinases
MPK-1	mitogen-activated protein kinase phosphatase-1
MTT	3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide
Na3VO4	sodium orthovanadate
NFkB	nuclear factor kappa B
NSAIDs	non-steroidal anti-inflammatory drugs
NO	nitric oxide (NO)
OA	Osteoarthritis
OPG	osteoprotegerin
Papp	apparent permeability coefficient
PBS	phosphate-buffered saline
PGE2	prostaglandin E2
PMSF	phenylmethanesulfonyl fluoride
PVDF	polyvinylidene difluoride
RHAMM	hyaluronan-mediated motility receptors
ROS	reactive oxygen species
TEER	transepithelial electrical resistance
T/C-28a2	human chondrocyte cells
TJ	tight junction
ZO-1	zonula occludens-1