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. 2022 Jul 14;13:884006. doi: 10.3389/fimmu.2022.884006

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Copyright © 2022 Jiang, Li, Zhang, Zhou, Guo, Zhou, Ming

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SEA pretreatment can prolong the survival time of mouse skin grafts. (A) In the control group (n=5) has no special treatment, and in the treatment group (n = 6), each mouse is given SEA 100 μg pretreatment 28 days later (3 times a week, 4 weeks in a row), and the outer ears of BALB/c donor mice were transplanted to the back of C57BL/6 recipient mice. (B) Compared with the control group (8.00 ± 0.36), the treatment group (11.67 ± 0.69) significantly prolonged the survival time of skin grafts (p < 0.01). (C, D) On the 9th day after transplantation, there was no obvious inflammation, ulcer, and necrosis in the skin grafts in the SEA treatment group. Compared with the control group, the graft rejection score was significantly lower than that of the control group (p < 0.01). (E) The pathological changes of the skin grafts were observed on the 7th day after transplantation. Compared with the control group, the low-power and high-power microscopes showed that the neutrophil cell aggregates decreased.