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. 2022 Jul 14;13:938391. doi: 10.3389/fphar.2022.938391

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Copyright © 2022 Hou, Kan, Wang, Shi, Zeng, Yang, Jiang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CAY10603 delays kidney function decline in the late stage of diabetic mice. (A) Schematic diagram of experimental design. (B) Serum creatinine and (C) serum BUN in different groups as indicated. (D) Representative images of PAS staining, Masson staining, and IHC staining of α-SMA and F4/80. (E) Quantification of the positive area for Masson staining. (F) Quantification of the positive area for α-SMA IHC staining. (G) Quantification of the positive area for F4/80 IHC staining. *p < 0.05; **p < 0.01; ***p < 0.001. Scale bar, 100 µm. Two-way ANOVA. CTL, control; Veh, vehicle.