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. 2022 Jul 28;12:12962. doi: 10.1038/s41598-022-17241-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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In vitro and in vivo neutralization of human sera with antibodies against SARS-CoV-2 N protein. (A) Neutralising titer of sera from Gabonese donors with (N positive) or without (N negative) Ab against SARS-CoV-2 N protein (n = 10/group). Standard sera from COVID-19 confirmed cases with high, medium and low neutralization capacity were used as positive control. Sera with neutralizing titer below the lowest tested dilution (dotted line), are plotted at 10. (B) Day 5 lung viral titer (TCID50/ml) in SARS-CoV-2 challenged mice (n = 6/group) pretreated with either PBS; 1 mg purified IgG from Gabonese sera with (N positive) or without (N negative) Ab against SARS-CoV-2 N protein; or from COVID-19 confirmed cases (confirmed) or with 50 μg polyclonal antibodies against SARS-CoV-2 N (pAb anti N). Mean ± SEM is depicted.