Figure 2.

Resolved structures of severe acute respiratory syndrome coronavirus 2 M^pro and RdRp. (a) A crystal structure of M^pro (PDB: 6Y2F [54]). The structure in cyan color is the M^pro; the molecule in yellow color is a α-ketoamide inhibitor binding to the protein. (b) A cryo-EM structure (PDB: 6M71 [55]) of RdRp (cyan) in complex with co-factors non-structural protein 7 (yellow) and non-structural protein 8 (brown). Blue and red colors on the sphere presentation of the protein structures indicate the positive and negative charged force fields, respectively