Table 1.
Examples of inhibitory peptides targeting spike protein - angiotensin-converting enzyme 2 interactions
| Sequences (names) | Sequence source |
|---|---|
| 21IEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNIT55 (inhibitor 1) | ACE2 [68] |
| 21IEEQAKTFLDNFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEI88 | ACE2 [68] |
| 349WDLGKGDFR357(inhibitor 2) | |
| 21IEEQAKTFLDNFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQALTVKLQLQALQQNGS105 | ACE2 [68] |
| 323MTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCT362 (inhibitor 3) | |
| 21IEEQAKTFLDNFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQALTVKL95 | ACE2 [68] |
| 335DPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGF400 (inhibitor 4) | |
| DEDLEELERLYRKAEEVAKEAKDASRRGDDERAKEQMERAMRLFDQVFELAQELQEKQTDGNRQKATHLDKAVKEAADELYQRVR (AHB1) | de Novo [70] |
| ELEEQVMHVLDQVSELAHELLHKLTGEELERAAYFNWWATEMMLELIKSDDEREIREIEEEARRILEHLEELARK (AHB2) | de Novo [70] |
| DKEWILQKIYEIMRLLDELGHAEASMRVSDLIYEFMKKGDERLLEEAERLLEEVER (LCB1) | de Novo [70] |
| SDDEDSVRYLLYMAELRYEQGNPEKAKKILEMAEFIAKRNNNEELERLVREVKKRL (LCB2) | de Novo [70] |
| NDDELHMLMTDLVYEALHFAKDEEIKKRVFQLFELADKAYKNNDRQKLEKVVEELKELLERLLS (LCB3) | de Novo [70] |
| QREKRLKQLEMLLEYAIERNDPYLMFDVAVEMLRLAEENNDERIIERAKRILEEYE (LCB4) | de Novo [70] |
| SLEELKEQVKELKKELSPEMRRLIEEALRFLEEGNPAMAMMVLSDLVYQLGDPRVIDLYMLVTKT (LCB5) | de Novo [70] |
| DREQRLVRFLVRLASKFNLSPEQILQLFEVLEELLERGVSEEEIRKQLEEVAKELG (LCB6) | de Novo [70] |
| DDDIRYLIYMAKLRLEQGNPEEAEKVLEMARFLAERLGMEELLKEVRELLRKIEELR (LCB7) | de Novo [70] |
| PIIELLREAKEKNDEFAISDALYLVNELLQRTGDPRLEEVLYLIWRALKEKDPRLLDRAIELFER (LCB8) | de Novo [70] |
| SALEEQLKTFLDKFMHELEDLLYQLAL (P8) | Derived* [71] |
| SALEEQYKTFLDKFM HELEDLLYQLSL (P9) | Derived* [71] |
| SALEEQYKTFLDKFMHELEDLLYQLAL (P10) | Derived* [71] |
| 19STIEEQAKTFLDKFNHEAEDLFYQSSL45 | ACE2 WT [72] |
| 24QAKTFLDKFNHEAEDLFYQSS44GLGKGDFR | ACE2 WT [72] |
| QVKYFLDKFNHEAEDRDYQSSL | ACE2 MT [72] |
| PFLEKLLHEAEDLLYQLELA | ACE2 MT [72] |
| PFLEKLLHEcdEDCLYQLELA | ACE2 MT [72] |
| 483VEGFNCYFPLQSYGFQPTNGVGY505 | RBD WT [72] |
*Peptides derived from ACE2 sequence“19STIEEQAKTFLDKFNHEAEDLFYQSSL45”. WT: Wild type, MT: Mutant, cd: D-cysteine, ACE2: Angiotensin-converting enzyme 2, RBD: Receptor-binding domain