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. Author manuscript; available in PMC: 2023 Aug 1.
Published in final edited form as: Kidney Int. 2022 May 23;102(2):370–381. doi: 10.1016/j.kint.2022.04.022

Figure 2. Results of logistic regression analysis for circulating proteins associated with risk of 10-year ESKD.

Figure 2.

A. Volcano plot of effect sizes (Odds Ratio per 1-quartile increase in concentration of circulating proteins) and strengths of associations (p value- y axis) with risk of 10-year ESKD. Proteins that are considered in 2nd stage are presented in the figure.

A total of 32 potential candidate proteins were significantly associated with risk of 10-year ESKD. Red indicates 11 proteins that were confirmed in all study cohorts.

B. Odds Ratios and 95% CIs for risk of 10-year ESKD are presented per 1-quartile increase in protein level for each of the 11 candidate proteins in each cohort (univariate logistic analysis) and in combined cohort (multivariable logistic analysis adjusted by sex, duration of diabetes, HbA1c, systolic blood pressure, eGFR, and ACR). See also Supplementary Table 1 and Table 2