Table 3. |.
Candidate proteins classified according to biological processes and relevance for mechanisms involved in kidney diseases.
| Target Full Name | Target | Biological Process in Gene Ontology Database | Cellular Component in Gene Ontology Database | Relevance for kidney diseases |
|---|---|---|---|---|
| Layilin | LAYN | Organic acid binding | No information | Profibrotic (17) |
| Endothelial cell-selective adhesion molecule | ESAM | Cell-cell junction assembly | Bicellular tight junction | Adhesion molecule of glomerulus (24,25) |
| Delta-like protein 1 | DLL1 | Neuron development related processes | Cytoplasmic vesicle | Profibrotic (18,19) |
| Fatty acid-binding protein, heart | FABP3 | Organic acid binding | Extracellular exosome | N/A |
| Mitogen-activated protein kinase 11 | MAPK11 | Negative regulation of muscle tissue | Nucleoplasm | Profibrotic (20) |
| Matrilin-2 | MATN2 | Neuron development related processes | No information | Profibrotic (21) |
| Neurexin-1-beta | NRX1B | Neuron development related processes | Component of membrane | Adhesion molecule of glomerulus (26) |
| Kallikrein-8 | KLK8 | Neuron development related processes | Secretory and cytoplasmic vesicle | N/A |
| Endostatin | Endostatin | Cell morphogenesis | Extracellular exosome | Profibrotic (22) |
| Reticulon-4 receptor | RTN4R | Neuron development related processes | Membrane raft | N/A |
| Tyrosine-protein kinase transmembrane receptor | ROR1 | Neuron development related processes | Actin filament bundle | Profibrotic (23) |