Fig 8. Proposed pathogenesis model in the development of endometriosis and the associated infertility based on the findings of this study.

Elevated UCA1 in endometriosis patients via RNA stabilization by functional SNPs can disrupt lipogenesis regulation by sponging key miRNAs with target genes involved in lipid metabolism. Such epigenetic regulation can further lead to reduced biosynthesis of triacyglycerol for oocyte future maturation and increased lipotoxicity, resulting in infertility.