Table 1. Genotypic and allelic distributions of five functional SNPs in UCA1 between Taiwanese endometriosis patients and controls1.
| SNPs | Genotype /allele | No. (%) of patients | HWE | No. (%) of controls | HWE | p-value | Corrected p-value2 | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|
| rs113579010 | GG | 8 | 0.854 | 3 | 0.663 | 0.520 | 1.000 | 3.322 (0.845–12.987) |
| AG | 48 | 35 | 1.709 (0.985–2.967) | |||||
| AA | 61 | 76 | 1.000 Reference | |||||
| G | 64 (27.4%) | 41 (13.2%) | 0.016* | 0.082 | 1.718 (1.101–2.674) | |||
| A | 170 (72.6%) | 187 (86.8%) | 1.000 Reference | |||||
| rs12462414 | TT | 30 | 0.854 | 29 | 0.132 | 0.599 | 1.000 | 1.212 (0.596–2.469) |
| GT | 61 | 52 | 1.375 (0.741–2.551) | |||||
| GG | 29 | 34 | 1.000 Reference | |||||
| T | 121 (50.4%) | 110 (47.8%) | 0.572 | 1.000 | 1.108 (0.772–1.592) | |||
| G | 119 (49.6%) | 120 (52.2%) | 1.000 Reference | |||||
| rs12610921 | GG | 3 | 0.000 | 3 | 0.000 | 0.787 | 1.000 | 1.333 (0.196–9.091) |
| GA | 100 | 91 | 1.464 (0.490–4.386) | |||||
| AA | 6 | 8 | 1.000 Reference | |||||
| G | 106 (48.6%) | 97 (47.5%) | 0.823 | 1.000 | 1.044 (0.712–1.529) | |||
| A | 112 (51.4%) | 107 (52.5%) | 1.000Reference | |||||
| rs73003273 | AA | 8 | 0.643 | 3 | 0.616 | 0.209 | 1.000 | 2.976 (0.759–11.628) |
| AG | 42 | 36 | 1.302 (0.750–2.257) | |||||
| GG | 69 | 77 | 1.000 Reference | |||||
| A | 58 (24.4%) | 42 (18.1%) | 0.097 | 0.583 | 1.458 (0.933–2.278) | |||
| G | 180 (75.6%) | 190 (81.9%) | 1.000 Reference | |||||
| rs73005445 | GG | 8 | 0.665 | 3 | 0.616 | 0.194 | 1.000 | 3.021 (0.770–11.765) |
| AG | 42 | 36 | 1.321 (0.760–2.294) | |||||
| AA | 68 | 77 | 1.000 Reference | |||||
| G | 58 (24.6%) | 42 (18.1%) | 0.088 | 0.525 | 1.475 (0.943–2.304) | |||
| A | 178 (75.4%) | 190 (81.9%) | 1.000 Reference |
1 Abbreviations: SNP, single nucleotide polymorphism; HWE, Hardy–Weinberg equilibrium; OR, odds ratio; CI, confidence interval
2 Bonferroni correction was applied to get the corrected p-value, which equals to p-value x5 in UCA1. Statistical significance: p-value < 0.05, *; p-value < 0.01, **; p-value < 0.001, ***.