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. 2022 Jul 28;17(7):e0271202. doi: 10.1371/journal.pone.0271202

Table 3. Up/Downregulated DEGs.

Gene symbol Adjusted P-value Fold change Gene title
ADA2 3.92E-57 1.553844 adenosine deaminase 2
BHLHA15 7.42E-58 1.588507 basic helix-loop-helix family, member a15
BTG2 1.07E-48 1.162589 BTG family, member 2
C16ORF54 3.83E-56 1.559668 chromosome 16 open reading frame 54
C3 9.22E-53 1.185639 complement component 3
C4B 1.95E-59 1.205283 complement component 4B (Chido blood group)
CCL18 1.34E-43 1.131173 chemokine (C-C motif) ligand 18
CCN1 3.80E-53 1.133135 cellular communication network factor 1
CCN2 4.85E-57 1.01127 cellular communication network factor 2
CD177 8.00E-57 1.096126 CD177 molecule
CD19 3.41E-64 1.192922 CD19 molecule
CD27 1.81E-45 1.813238 CD27 molecule
CD38 8.02E-43 1.551755 CD38 molecule
CD79A 5.19E-50 1.947502 CD79a molecule, immunoglobulin-associated alpha
CFI 6.18E-44 1.00665 complement factor I
COL15A1 3.12E-41 1.205063 collagen, type XV, alpha 1
COL4A1 4.04E-54 1.160181 collagen, type IV, alpha 1
COL4A2 3.09E-46 1.1936 collagen, type IV, alpha 2
CORO1A 8.85E-43 1.042673 coronin, actin binding protein, 1A
CPNE5 5.56E-53 1.308945 copine V
CSF2RB 1.49E-32 1.173406 colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSF3 6.58E-29 1.259706 colony stimulating factor 3
CTSH 1.38E-52 1.034782 cathepsin H
CXCL1 9.72E-45 1.891672 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL12 1.96E-57 1.075039 chemokine (C-X-C motif) ligand 12
CXCL13 4.72E-53 1.392421 chemokine (C-X-C motif) ligand 13
CXCL6 2.39E-38 2.008496 chemokine (C-X-C motif) ligand 6
CXCL8 8.48E-35 1.275532 chemokine (C-X-C motif) ligand 8
CXCR4 4.07E-41 1.763415 chemokine (C-X-C motif) receptor 4
CYP24A1 1.45E-48 1.376211 cytochrome P450, family 24, subfamily A, polypeptide 1
CYTIP 6.14E-57 1.615435 cytohesin 1 interacting protein
DDIT4L 1.16E-60 1.051272 DNA-damage-inducible transcript 4-like
DERL3 5.72E-39 1.013822 derlin 3
DNAJB9 1.63E-53 1.022911 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 1.06E-36 1.049658 dual specificity phosphatase 5
EGFL6 2.65E-46 1.102904 EGF-like-domain, multiple 6
ENPP2 4.46E-49 1.133815 ectonucleotide pyrophosphatase/phosphodiesterase 2
EVI2B 3.21E-26 1.498001 ecotropic viral integration site 2B
FCGR2B 3.37E-37 1.249936 Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR3A 1.95E-29 1.132553 Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
FCGR3B 3.23E-56 1.342826 Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FCN1 3.76E-25 1.011778 ficolin (collagen/fibrinogen domain containing) 1
FCRL5 9.33E-45 1.455488 Fc receptor-like 5
FCRLA 1.09E-31 1.402519 Fc receptor-like A
FKBP11 1.04E-46 1.42036 FK506 binding protein 11
FOS 1.75E-44 1.290024 FBJ murine osteosarcoma viral oncogene homolog
HBA1 5.87E-36 1.14025 hemoglobin, alpha 1
HCLS1 2.79E-44 1.210277 hematopoietic cell-specific Lyn substrate 1
HSPA13 5.84E-58 1.159802 heat shock protein 70kDa family, member 13
ICAM2 1.63E-43 1.347935 intercellular adhesion molecule 2
IGLL5 3.07E-65 2.336454 immunoglobulin lambda-like polypeptide 5
IL10RA 3.18E-43 1.354325 interleukin 10 receptor, alpha
IL1B 2.82E-38 1.092466 interleukin 1 beta
IL2RG 6.34E-45 1.100459 interleukin 2 receptor, gamma
ITM2C 7.28E-47 1.184677 integral membrane protein 2C
JCHAIN 6.48E-49 1.286419 joining chain of multimeric IgA and IgM
LAX1 6.21E-59 1.652774 lymphocyte transmembrane adaptor 1
LY96 6.74E-45 1.12351 lymphocyte antigen 96
MME 9.12E-20 1.282694 membrane metallo-endopeptidase
MMP1 3.92E-57 1.025763 matrix metallopeptidase 1
MMP12 5.57E-59 1.466344 matrix metallopeptidase 12
MMP13 5.12E-54 1.178796 matrix metallopeptidase 13
MMP3 9.63E-57 1.040563 matrix metallopeptidase 3
MMP7 1.34E-34 1.51808 matrix metallopeptidase 7
MZB1 7.94E-43 2.407337 marginal zone B and B1 cell-specific protein
NCF4 1.49E-21 1.195206 neutrophil cytosolic factor 4
ODAM 1.33E-48 1.483623 odontogenic, ameloblast associated
P2RY8 1.21E-32 1.215359 purinergic receptor P2Y, G-protein coupled, 8
PDZRN4 2.52E-23 1.289339 PDZ domain containing ring finger 4
PECAM1 3.01E-28 1.098606 platelet/endothelial cell adhesion molecule 1
PIM2 4.14E-44 1.325032 Pim-2 proto-oncogene, serine/threonine kinase
PLAC8 3.25E-54 1.260461 placenta specific 8
PLAT 4.49E-46 1.43498 plasminogen activator, tissue
PLPP5 1.40E-51 1.0399 phospholipid phosphatase 5
PNOC 5.11E-71 1.387546 prepronociceptin
POU2AF1 6.04E-52 2.388694 POU class 2 associating factor 1
PPBP 1.82E-22 1.041058 pro-platelet basic protein
PROK2 4.58E-35 1.042763 prokineticin 2
PTP4A3 6.34E-57 1.07086 protein tyrosine phosphatase type IVA, member 3
RAC2 1.11E-43 1.173037 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RGS1 1.19E-45 1.196332 regulator of G-protein signaling 1
RGS4 3.12E-50 1.154445 regulator of G-protein signaling 4
RHOH 1.54E-47 1.262168 ras homolog family member H
RNASE6 8.98E-38 1.065063 ribonuclease, RNase A family, k6
SASH3 2.65E-37 1.005489 SAM and SH3 domain containing 3
SEL1L3 1.43E-54 1.097714 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELE 4.59E-23 1.235928 selectin E
SELENOM 8.56E-43 1.199581 selenoprotein M
SELL 6.58E-22 1.458 selectin L
SERPINI1 6.35E-12 1.038916 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP4 9.20E-39 1.32865 secreted frizzled-related protein 4
SLAMF7 9.87E-41 1.619179 SLAM family member 7
SPAG4 5.26E-38 2.09838 sperm associated antigen 4
SRGN 1.36E-66 1.043883 serglycin
ST6GAL1 8.80E-11 1.051981 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TAGAP 1.73E-34 1.11477 T-cell activation RhoGTPase activating protein
TENT5C 3.19E-45 2.014512 terminal nucleotidyltransferase 5C
THEMIS2 1.45E-45 1.330465 thymocyte selection associated family member 2
TNFRSF17 2.93E-31 2.349733 tumor necrosis factor receptor superfamily, member 17
VCAN 2.92E-39 1.038621 versican
ZNF275 2.71E-48 1.062687 zinc finger protein 275
AADAC 3.00E-42 -1.20712 arylacetamide deacetylase
AADACL2 1.08E-41 -2.01688 arylacetamide deacetylase-like 2
ABCA12 6.64E-33 -1.16284 ATP binding cassette subfamily A member 12
ATP6V1C2 1.23E-53 -1.14311 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2
BPIFC 3.48E-44 -1.25704 BPI fold containing family C
CALML5 6.56E-27 -1.26108 calmodulin-like 5
CLDN20 6.70E-54 -1.28623 claudin 20
COBL 6.96E-56 -1.00726 cordon-bleu WH2 repeat protein
DSC1 1.76E-37 -2.14211 desmocollin 1
ELOVL4 1.09E-40 -1.25365 ELOVL fatty acid elongase 4
EPCAM 3.33E-36 -1.09877 epithelial cell adhesion molecule
FAM83C 3.12E-50 -1.02485 family with sequence similarity 83, member C
FLG 1.06E-18 -1.22646 filaggrin
FLG2 2.61E-27 -1.68284 filaggrin family member 2
KRT1 7.92E-11 -1.09036 keratin 1, type II
KRT2 3.04E-17 -1.5992 keratin 2, type II
LCE2B 1.67E-24 -1.0645 late cornified envelope 2B
LOR 1.67E-14 -1.32218 loricrin
MAMDC2 7.12E-24 -1.13528 MAM domain containing 2
NEFL 4.06E-49 -1.21988 neurofilament, light polypeptide
NPR3 3.87E-52 -1.09761 natriuretic peptide receptor 3
POF1B 1.36E-48 -1.08209 premature ovarian failure, 1B
RPTN 4.38E-15 -1.07675 repetin
SLC16A9 5.53E-43 -1.0713 solute carrier family 16, member 9
SLC19A2 8.89E-41 -1.04423 solute carrier family 19 (thiamine transporter), member 2
SLC27A6 2.00E-37 -1.26819 solute carrier family 27 (fatty acid transporter), member 6
SPAG17 4.10E-51 -1.19574 sperm associated antigen 17