Figure 2. In mesenteric resistance arteries from female mice, inhibition of MCU (mitochondrial Ca²⁺ uniporter) by treatment with mtCaMKIIN reduces vasodilation to a larger extent than in male mice.

A, Acetylcholine (ACh)‐induced vasodilation of second‐order mesenteric arteries from male and female mice with endothelium‐specific expression of mitochondria‐targeted CaMKIIN (e‐mtCaMKIIN) and in littermate control (wild‐type [WT]) mice. B, EC₅₀ of vasodilation to Ach as in (A). C, EMax of vasodilation to ACh as in (A). D, Endothelium‐independent vasodilation to sodium nitroprusside (SNP). E, Vasoconstriction to KCl. Analysis by repeated‐measure 2‐way ANOVA (A, D, and E) and 2‐way ANOVA (B and C). No significant interactions between sex and genotype were seen for Figure 1B and 1C. P values for source of variations in treatment groups as shown. *P<0.05, **P<0.01, ***P<0.005. EC₅₀ indicates half maximal effective concentration; EMax, maximal effect; mtCaMKIIN, mitochondrially targeted peptide inhibitor of CaMKII; KCl, potassium chloride.