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. 2016 Dec 5;25(1):119–124. doi: 10.1016/j.jfda.2016.10.016

Figure 2.

Figure 2

Apple polyphenol phloretin inhibits growth of cancer cells through inhibition of type 2 glucose transporter. Our groups have demonstrated that phloretin can induce growth arrest of cells in the G0/G1 phase, induce apoptotic cell death, and inhibit tumor cells migration and metastasis. All these effects can be attributed to the phloretin-induced intracellular glucose deprivation.