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. 2022 Jul 14;12:934870. doi: 10.3389/fonc.2022.934870

Table 3.

Comparisons of Characteristics between different portal hypertension grades after Propensity Score Matching.

Characteristics Total (N= 186) PH grade 0 (N= 62) PH grade 1 (N= 62) PH grade 2 (N= 62) P value
Age, years 52 (45 - 58) 51 (45 - 56) 54 (45 - 57.8) 53.5 (46 - 58.8) 0.178
Gender 0.882
Female 22 (11.83) 6 (9.68) 8 (12.9) 8 (12.9)
Male 164 (88.17) 56 (90.32) 54 (87.1) 54 (87.1)
ASA classification 0.711
Grade 1 47 (25.27) 14 (22.58) 15 (24.19) 18 (29.03)
Grade 2 121 (65.05) 44 (70.97) 40 (64.52) 37 (59.68)
Grade 3 18 (9.68) 4 (6.45) 7 (11.29) 7 (11.29)
Etiology
HBV 0.732
NO 17 (9.14) 7 (11.29) 4 (6.45) 6 (9.68)
YES 169 (90.86) 55 (88.71) 58 (93.55) 56 (90.32)
HCV 0.999
NO 182 (97.85) 60 (96.77) 61 (98.39) 61 (98.39)
YES 4 (2.15) 2 (3.23) 1 (1.61) 1 (1.61)
Alcoholic 0.999
NO 183 (98.39) 61 (98.39) 61 (98.39) 61 (98.39)
YES 3 (1.61) 1 (1.61) 1 (1.61) 1 (1.61)
Others 0.776
NO 176 (94.62) 58 (93.55) 60 (96.77) 58 (93.55)
YES 10 (5.38) 4 (6.45) 2 (3.23) 4 (6.45)
HBV DNA 0.900
<500 Copys 95 (51.08) 32 (51.61) 30 (48.39) 33 (53.23)
>500 Copys 91 (48.92) 30 (48.39) 32 (51.61) 29 (46.77)
Cirrhosis status 0.999
NO 4 (2.15) 1 (1.61) 1 (1.61) 2 (3.23)
YES 182 (97.85) 61 (98.39) 61 (98.39) 60 (96.77)
Surgical approach 0.688
Laparoscopy 83 (44.62) 30 (48.39) 25 (40.32) 28 (45.16)
Open 103 (55.38) 32 (51.61) 37 (59.68) 34 (54.84)
Extent of resection 0.999
Minor 175 (94.09) 58 (93.55) 59 (95.16) 58 (93.55)
Major 11 (5.91) 4 (6.45) 3 (4.84) 4 (6.45)
Hepatic inflow occlusion 0.891
NO 65 (34.95) 20 (32.26) 23 (37.1) 22 (35.48)
YES 121 (65.05) 42 (67.74) 39 (62.9) 40 (64.52)
Intraoperative blood loss 0.999
<400 ml 118 (63.44) 39 (62.9) 39 (62.9) 40 (64.52)
≥400 ml 68 (36.56) 23 (37.1) 23 (37.1) 22 (35.48)
Intraoperative transfution 0.743
NO 138 (74.19) 48 (77.42) 44 (70.97) 46 (74.19)
YES 48 (25.81) 14 (22.58) 18 (29.03) 16 (25.81)
Tumor number 0.962
Single 162 (87.1) 53 (85.48) 55 (88.71) 54 (87.1)
Multipe(≥2) 24 (12.9) 9 (14.52) 7 (11.29) 8 (12.9)
Tumor size, cm 3 (2 - 4) 3.5 (2.7 - 4.9) 3 (2 - 3.6) 3 (2 - 4) 0.515
ALT, U/L 34 (23 - 45) 34 (25 - 51.8) 36 (23 - 50.5) 33 (23 - 43) 0.425
AST, U/L 32 (24 - 47) 31.5 (23 - 46.8) 35.5 (25 - 52.8) 32.5 (24.2 - 44) 0.828
Albumin, g/L 38.8 (35 - 41) 39.2 (37.1 - 42.1) 37.8 (34.1 - 40.9) 38 (35.5 - 40.2) 0.379
Total bilirubin, μmol/L 16.8 (11.9 - 21.3) 16.4 (11.9 - 21) 17.9 (12.1 - 25.1) 16.6 (11.8 - 19.8) 0.566
Creatinine, μmol/L 77 (65 - 84) 77.5 (65 - 84) 76.5 (62.5 - 83) 77.5 (69.2 - 86.5) 0.614
PT, s 13.4 (12.3 - 14.8) 13.6 (12 - 14.8) 13.1 (12.1 - 14.2) 13.5 (12.5 - 14.8) 0.854
RBC, 1012/L 4.4 (4 - 4.8) 4.5 (3.9 - 4.9) 4.3 (4.1 - 4.7) 4.4 (3.9 - 4.8) 0.479
AFP, ng/ml 60.7 (12.1 - 619.7) 159.1 (16 - 773.2) 37.8 (7.8 - 527.4) 37.1 (12.1 - 540.1) 0.449
Platelet, 109/L 90.5 (65.6 - 149) 160.5 (114.5 - 176) 92 (71.8 - 149) 63.5 (50.1 - 81) 0.006
Child-Pugh class 0.652
Grade A 165 (88.71) 54 (87.1) 57 (91.94) 54 (87.1)
Grade B 21 (11.29) 8 (12.9) 5 (8.06) 8 (12.9)
Meld score 6.2 (4.5 - 8.2) 6.2 (4.7 - 8.2) 6.2 (4.8 - 8.3) 6.4 (4.3 - 8.1) 0.587
PHLF 0.041
NO 131 (70.43) 48 (77.42) 47 (75.81) 36 (58.06)
YES 55 (29.57) 14 (22.58) 15 (24.19) 26 (41.94)

PH, portal hypertension; ASA, American Society of Anesthesiologists; HBV, Hepatitis B virus; HCV, Hepatitis C virus; ALT, alanine transaminase; AST, aspartate transaminase; PT, prothrombin time; RBC, red blood cell; AFP, a-fetoprotein level; MELD, Model For End-Stage Liver Disease; PHLF, post hepatectomy liver failure. Values with P < 0.05 in the tables are in bold.