Table 4.
Factors Associated with Post Hepatectomy Liver Failure at Univariate and Multivariate Logistic Regression Analyses after Propensity Score Matching.
| Characteristics | Univariable logistic regression | Multvariable logistic regression | ||
|---|---|---|---|---|
| 0R (95%CI) | P value | 0R (95%CI) | P value | |
| Age, years | 1.059 (1.022-1.101) | 0.002 | 1.05 (1.008-1.097) | 0.022 |
| Gender, male | 1.491 (0.555-4.736) | 0.456 | ||
| ASA classification | 1.108 (0.532-0.707) | 0.268 | ||
| grade 2 vs grade1 | 1.107 (0.532-2.400) | 0.789 | ||
| grade 3 vs grade1 | 1.308 (0.388-4.153) | 0.653 | ||
| Etiology | ||||
| HBV, Yes | 0.567 (0.206-1.641) | 0.276 | ||
| HCV, Yes | 2.434 (0.286-20.717) | 0.38 | ||
| Alcoholic, Yes | 1.194 (0.055-12.722) | 0.886 | ||
| others, Yes | 1.634 (0.404-5.961) | 0.461 | ||
| HBV DNA, >500 copy | 1.698 (0.902-3.236) | 0.103 | ||
| Cirrhosis, Yes | 6778148.135 (0-) | 0.99 | ||
| Surgical approach, Open surgery | 1.058 (0.562-2.008) | 0.861 | ||
| Extent of resection, Major | 4.63 (1.337-18.343) | 0.018 | 4.154 (1.032-18.616) | 0.048 |
| Hepatic inflow occlusion, Yes | 1.293 (0.666-2.578) | 0.455 | ||
| Intraoperative Blood loss, ≥400 ml | 1.104 (0.571-2.107) | 0.766 | ||
| Intraoperative transfution, Yes | 1.114 (0.536-2.246) | 0.767 | ||
| Tumor number, Multipe | 1.857 (0.751-4.459) | 0.169 | ||
| Tumor size, cm | 1.039 (0.868-1.236) | 0.664 | ||
| ALT, ≥40 U/L | 1.829 (0.956-3.499) | 0.067 | 1.643 (0.668-4.048) | 0.277 |
| AST, ≥40 U/L | 1.968 (1.031-3.764) | 0.04 | 1.058 (0.408-2.689) | 0.907 |
| Albumin, <35 g/L | 2.831 (1.382-5.815) | 0.004 | 1.806 (0.751-4.339) | 0.184 |
| Total bilirubin, ≥17.2 μmol/L | 1.806 (0.959-3.446) | 0.069 | 1.794 (0.846-3.874) | 0.13 |
| PT, ≥15s | 1.761 (0.825-3.691) | 0.137 | ||
| RBC, <3.5*1012/L | 2.617 (0.914-7.507) | 0.069 | 1.259 (0.33-4.51) | 0.727 |
| AFP, ≥400 ng/ml | 0.693 (0.339-1.366) | 0.3 | ||
| Child-Pugh score, (B class vs A class) | 3.783 (1.499-9.876) | 0.005 | 1.661 (0.543-5.149) | 0.371 |
| MELD score | 1.053 (0.943-1.178) | 0.359 | ||
| PH grade | 1.094 (0.475-0.514) | 0.212 | ||
| grade 1 vs grade0 | 1.094 (0.475-2.535) | 0.832 | 0.928 (0.37-2.331) | 0.873 |
| grade 2 vs grade0 | 2.476 (1.149-5.513) | 0.023 | 2.559 (1.106-6.151) | 0.031 |
PHLF, post hepatectomy liver failure; ASA, American Society of Anesthesiologists; HBV, Hepatitis B virus; HCV, Hepatitis C virus; ALT, alanine transamise; AST, aspartate transamise; PT, prothrombin time; RBC, red blood cell; AFP, a-fetoprotein level; MELD, Model For End-Stage Liver Disease; PH, portal hypertension. Values with P < 0.05 in the tables are in bold.