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Genetic pedigrees supported the autosomal recessive inheritance of syndromic obesity in the cases. (a, b, d) The Sanger sequencing chromatograms of homozygous affected, homozygous normal, and heterozygous carrier individuals for the novel variants in MKKS (BBS6), BBS7, and ALMS1 genes. (c) The confirmation of the known pathogenic variant in the BBS12 gene through Sanger sequencing in the proband.
