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. 2022 Jul 28;12:12940. doi: 10.1038/s41598-022-17314-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Schematics of the experimental setup and dye infiltration test. (a) Pressure profile along the longitudinal and transverse plane of the FUS focus (bar = 10 mm). (b) Illustration of the temporal features of sonication parameters used in the experiment. (c) Experimental setup for TbO dye infiltration into the melamine block (shown without the TbO solution, inset: microscopic view of the foam, bar = 100 μm). (d) A setup for sonicating the agar block shown without the dye solution. The chamber contained guide slots to position the acoustic focus at 1 mm in front of the surface of the block. The green cones illustrate the FUS sonication to the target.